ea0009oc24 | Oral Communication 3: Neuroendocrinology | BES2005
Druce M
, Neary N
, Small C
, Monteiro M
, Thompson E
, Ghatei M
, Bloom S
The gastric hormone ghrelin stimulates feeding whereas the intestinal hormones peptide YY3-36 (PYY3-36) and oxyntomodulin inhibit feeding. In order to determine whether these gut hormones retain their effects in obesity, they were administered in vivo intraperitoneally to unanaesthetised lean and obese mice. Forty eight C57Bl/6 male mice were randomised to receive either low-fat diet (4.5% fat) or high fat diet (60% fat). After 16 weeks, mice fed o...